What is the significance of the number 5?
4 + 1 = 5 = man mingled with God
What does the number five signify? This is quite easy to understand.
The ten commandments were divided into two tablets each containing five commandments. In Matthew 25, we have ten virgins divided into two groups of five. If you look at yourself, you will see that you have ten fingers and ten toes, all arranged in groups of five. The five fingers on each of your hands are composed of four plus one. If you had two thumbs and three fingers, it would be awkward for you to do anything. But with one thumb and four fingers we can easily do anything. The thumb is number one, representing the one God as the Creator. Four is the number of God’s creature, like the four living creatures (Rev. 4:6). Thus, four plus one means man, God’s creature, plus God.
(Life-Study of Genesis, Chapter 30, Section 2)